Error 15227 specifies that some essential files required to run QuickBooks are not responding. The reason that triggers QuickBooks error 15227 could be corrupted or damaged QuickBooks software, an incomplete Windows installation, virus or malware intrusion or you might have mistakenly deleted some necessary QuickBooks files. However, the problem can be easily resolved by using some simple steps. Firstly, you will need to repair the registries that triggered error 15227 in QuickBooks.