Sofosbuvir tablets 400 mg use are to successfully treat chronic hepatitis C (a viral infection that causes liver damage). This medication is a nucleotide analog inhibitor. sofosbuvir tablets 400 mg use are to lower the amount of hepatitis C virus in your body and improve your liver function. Additionally, they are taken once a day with or without food. The recommended dose is 400 mg, taken for 12 weeks. Common side effects of sofosbuvir include fatigue, headache, nausea, and diarrhoea.